Another word for presence7/12/2023 ![]() A mortality rate statistically modified to eliminate the effect of different age distributions in the different populations. I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. ![]() I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. IB is supported by a NIHR Senior Investigator award. DH is funded by an NIHR Post-doctoral Fellowship (PDF-2018-11-ST2-006). AJE receives support from the NIHR HPRU in Emergency Response. The views expressed are those of the authors and not necessarily those of the NIHR, the Department of Health and Social Care or the UKHSA. This project was supported by the National Institute for Health and Care Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections (NIHR-200910), a partnership between the UK Health Security Agency (UKHSA), the University of Liverpool and the University of Warwick. The authors have declared no competing interest. SARS-CoV-2 exposure may be associated with new post-infection gastrointestinal illness Most studies identified are at high risk of bias and of low quality This systematic review evaluates the evidence across 28 observational studies The burden of gastrointestinal illness after acute SARS-CoV-2 infection is not known Furthermore, we show the need for high-quality research to better understand the SARS-CoV-2 association with gastrointestinal symptoms, particularly as population exposure to enteric infections returns to pre-COVID-19-restriction levels.Īcute SARS-CoV-2 infection can result in gastrointestinal symptoms Our review has shown that, from a limited pool of mostly low-quality studies, previous SARS-CoV-2 exposure may be associated with ongoing gastrointestinal symptoms and the development of functional gastrointestinal illness. We also identified the presence of functional gastrointestinal disorders in historically SARS-CoV-2 exposed individuals. For six studies at a low risk of methodological bias, the symptom prevalence ranged from 0.2% to 24.1% with a median follow-up time of 13 weeks. The weighted pooled prevalence for persistent gastrointestinal symptom of any nature and duration was 10.7%, compared to 4.9% in healthy controls. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools. Two reviewers independently identified 28 eligible articles which followed participants for various gastrointestinal outcomes after acute SARS-CoV-2 infection. We searched scientific literature using MedLine, SCOPUS, Embase, Europe PubMed Central, medRxiv and Google Scholar from December 2019 to October 2022. We conducted a systematic review to examine the prevalence of persistent gastrointestinal symptoms and the incidence of new gastrointestinal illness following acute SARS-CoV-2 infection. For some, these symptoms may persist beyond acute infection, in what is known as ‘post-COVID syndrome’. It is known that SARS-CoV-2 infection can result in gastrointestinal symptoms.
0 Comments
Leave a Reply. |